We have developed and established a metabolomics platform technology which enables systematic quantification of many classes of relevant biological metabolites in cells, tissues, or body fluids. The technology comprises an automated sample preparation workflow integrated with sensitive mass-spectrometric methods as well as a tailor-made software solution (MetIDQ Software) which controls sample management, data collection, data validation, and analysis. Many hundred of metabolites can be identified and quantified using this novel technology platform.
Our technology platform offers MS-based LC-, FIA-MS/MS and GC-MS quantification of metabolites through multiple reaction monitoring (MRM), employing triple quadrupole state of the art mass spectrometers. We have established effective metabolite extraction methods and standardized sample preparation.
Identification and quantification of more than 630 annotated endogenous metabolites