Potential Research Questions
Can progression of kidney disease be prevented?
How does kidney function relate to heart disease and other complications?
Can –omics provide novel treatment approaches?
Which transplantation patients are at risk for rejection?
Status Quo and Medical Need
In spite of high numbers of kidney diseases, treatment options are limited. Many patients are only diagnosed at an advanced stage – at a time when the renal tissue that hardly regenerates is irreplaceably damaged.
Renal disease strongly increases the risk for conditions such as heart failure. Also, impaired kidney function limits the therapeutic choices for many diseases. With rising diabetes numbers, the numbers of patients with kidney disease are also likely to increase, further progress to control kidney disease is an urgent need.
Besides being a site of metabolite anabolism and catabolism, the kidneys have an important role in maintaining homeostasis through the excretion of metabolic waste products.
Biocrates is a partner in the SysKid research consortium.
Relevant Metabolite Classes
- Impaired mitochondrial function, reflected by altered acylcarnitine levels, is well described in renal function decline.
- Symmetric dimethylarginine (SDMA) is hardly metabolized, and elimination relies on renal excretion. In kidney function decline or kidneytoxicity, SDMA levels are expected to increase.
- The tryptophan to kynurenine ratio has been suggested as marker for kidney function.
- Produced by adrenal glands and cleared by kidneys.
- Blood pressure is co-regulated by steroid hormones. Sustained hypertension is a major reason for kidney function decline.
- Bassi et al.: Metabolomic profiling in individuals with a failing kidney allograft; PLOS One 2017
- Braun et al.: Altered lipid metabolism in the aging kidney identified by three layered omic analysis; Aging 2016
- Nikolaeva et al.: Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition; Journal of the American Society of Nephrology 2016
- Blydt-Hansen et al.: Urinary Metabolomics for Noninvasive Detection of Borderline and Acute T Cell-Mediated Rejection in Children After Kidney Transplantation; Am. J. Transplant. 2014
- Pena et al.: Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus; Diabet. Med. 2014
- Goek et al.: Metabolites associate with kidney function decline and incident chronic kidney disease in the general population; Nephrol. Dial. Transplant. 2013
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For Research Use Only. Not for use in diagnostic procedures.